Ponty sit at the football of the table and remain without a win to their name in the league this season after suffering a narrow 2-1 home defeat to Cascade in their most recent outing.
Caldicot are three points better off in sixth place, but have a significantly better goal difference so are unlikely to be overtaken by Ponty this weekend even if the hosts triumph.
Kellan Webb’s side triumphed 4-2 over Pontardawe in January, which is their only league victory across the last two league campaigns.
Earlier in the campaign, a Renee Day brace inspired Ponty to a 4-2 victory over Caldicot in the Genero Adran Trophy group stage.
